Arthrohills Capsule
Herbal Hills® brand formulation · Joint Support · clinical study summary
Arthrohills Capsule is a Herbal Hills joint care formulation made by the Siddha Ghruta method. It has been evaluated in a CTRI-registered 90-day open-label study in 33 adults and in a 21-day safety and tolerability study in 30 adults, published in the International Journal of Research in Ayurveda and Medical Sciences (2021).
Study at a Glance
Clinical study on the Herbal Hills® Arthrohills Capsule formulation
| Field | Study A (Registered Trial) | Study B (Published Safety Study) |
|---|---|---|
| Study title | An Open Label, Prospective, Multicentre, Clinical study to evaluate efficacy and safety of Arthrohills Capsules in subjects suffering from Osteoarthritis of Knee(s) | A Safety Evaluation and Tolerability of Arthohills Capsule an Ayurveda Formulation in Osteoarthritis Subjects |
| Registration / journal | CTRI/2017/06/008786, registered 08/06/2017 | Int J Res Ayurveda Med Sci 2021; 4(1): 22–27 (ISSN 2582-2748) |
| Design | Open-label, prospective, single-arm; IEC approved | Observational, non-comparative, prospective; IEC approved, ICMR guidelines |
| Participants | 33 adults with mild to moderate knee osteoarthritis | 30 adults aged 40–70 with knee osteoarthritis |
| Dose and duration | 2 capsules daily, morning, empty stomach, with lukewarm water or milk; 90 days | 2 capsules (500 mg) twice a day; 21 days |
| Measures | VAS pain, WOMAC, time to walk 50 feet, quality of life, global evaluation, adverse events, lab tests | VAS pain, WOMAC (pain, stiffness, physical function), haematology, knee X-ray, adverse events |
| Sponsor | Herbal Hills (Isha Agro Developers Pvt Ltd) | Herbal Hills; conducted at Vishwanand Kendra, Pune |
Composition
Each soft gel capsule contains Arthrohills Ghruta 500 mg, processed by the Siddha Ghruta method with cow ghee and cow milk and the following herbs (as published):
| Ingredient | Botanical Name | Part | Quantity |
|---|---|---|---|
| Sunthee | Zingiber officinale | Rhizome | 22.75 mg |
| Shallaki | Boswellia serrata | Gum resin | 45.45 mg |
| Shuddha Guggul | Balsamodendron mukul | Gum resin | 45.45 mg |
| Shuddha Laksha | Laccifer lacca | Resin | 45.45 mg |
| Nirgundee | Vitex negundo | Whole plant | 45.45 mg |
| Methi | Trigonella foenum-graecum | Seeds | 45.45 mg |
| Asthishrunkhala | Vitis quadrangularis | Stem | 45.45 mg |
| Maharasnadi | Generic preparation | — | 90.90 mg |
| Dashmooladi | Generic preparation | — | 90.90 mg |
| Chopchinee | Rheum emodi | Root | 22.75 mg |
| Go Ghrit / Go Dugdha | Cow ghee / cow milk | — | Processing base |
Key Results
| Measure | Baseline | End of Study | Change |
|---|---|---|---|
| Study A: VAS pain score (mean ± SD) | 68.93 ± 15.40 | 31.88 ± 14.47 (day 90) | −53.7%, p<0.05 |
| Study A: WOMAC pain score | — | — | −48.84% |
| Study A: WOMAC stiffness score | — | — | −53.95% |
| Study A: investigator global assessment | — | — | 81.81% showed minimum to much improvement |
| Study A: needed paracetamol for pain | — | — | 6.06% of participants |
| Study B: VAS pain score | 40.28 ± 4.78 | 23.78 ± 2.01 (day 21) | −41.0%, p<0.001 |
| Study B: WOMAC total | 48.21 | 27.12 | −43.7%, p<0.001 |
| Study B: WOMAC pain sub-score | 10.22 | 4.11 | −59.8% |
| Study B: WOMAC stiffness sub-score | 3.05 | 1.03 | −66.2% |
| Study B: WOMAC physical function | 34.11 | 21.67 | −36.5% |
In Study A, mean knee pain on the VAS fell steadily at every 15-day visit, from 68.93 at baseline to 31.88 at day 90. In Study B, VAS pain fell from 40.28 to 23.78 over 21 days, and every WOMAC sub-score improved significantly (p<0.001). Percentages in the table are calculated from the published means.
Private Label Availability
The Herbal Hills® Arthrohills Capsule formulation is available for private label and third party manufacturing at Herbal Hills, Lonavala. The study above was conducted on the Herbal Hills® Arthrohills Capsule and supports the formulation only; a product launched under your brand name is subject to its own licences and approvals.
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